With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4295-99-2,4-Cyanotetrahydro-4H-pyran,as a common compound, the synthetic route is as follows.
To a solution of tetrahydro-2H-pyran-4-carbonitrile (2.15 g, 19.34 mmol) in dry THE (15 mL) cooled at -78 C, LiHDMS solution (1M in THE, 24.2 mL, 24.2 mmol) was added dropwise under nitrogen atmosphere and the mixture was stirred at this temperature for lh. Then, a solution of (3-iodopropoxy)methylbenzene (6.14 g, 22.2 mmol) in dry THE (10 mL) was added and the reaction mixture was allowed to reachrt and stirred overnight. The solvent was evaporated and the residue was diluted with water and Et20. The phases were separated and the aqueous phase was extracted several times with Et20. The organic phases were combined and washed with water and brine, the solvent was evaporated and the residue thus obtained was purified by flash chromatography on silica gel, gradient CH to CH:AcOEt (80:20) to give the titlecompound (4.35 g, 87% yield).HPLC-MS (Method B): Ret, 2.28 mm; ESI+-MS mlz, 260.31 (M+H).
As the paragraph descriping shows that 4295-99-2 is playing an increasingly important role.
Reference£º
Patent; LABORATORIOS DEL DR. ESTEVE, S.A.; GARCIA-LOPEZ, Monica; ALMANSA-ROSALES, Carmen; (168 pag.)WO2018/108319; (2018); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics