108-55-4, Dihydro-2H-pyran-2,6(3H)-dione is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: To a suspension of 48.6 mmol of the proper phenyl derivative and 71.3 mmol of AlCl3 in 60 mL of dry DCM, cooled at 0C, a solution of 32.4 mmol of the proper anhydride in 30 mL of dry DCM was added. The reaction was stirred at rt for 12 h except for the synthesis of 10, which needed only 1 h to proceed to completion. The mixture was then quenched with water and concentrated sulfuric acid; the organic phase was separated from the aqueous one and the solvent evaporated under vacuum. The residue was dissolved in EtOAc, extracted with a 10% NaOH aqueous solution, then acidified with a 1N HCl aqueous solution and re-extracted with EtOAc. Finally the organic phase was dried over MgSO4, filtered and concentrated in vacuo to afford pure compounds 11-13. 5-(3,4-dimethoxyphenyl)-5-oxopentanoic acid (11) 92% yield. 1H NMR (300 MHz, CDCl3): delta = 7.51-7.54 (m, 1H), 7.47 (s, 1H), 6.82 (d, 1H, J = 9.1 Hz), 3.88 (s, 3H), 3.87 (s, 3H), 2.97 (t, 2H, J = 7.8 Hz), 2.44 (t, 2H, J = 7.8 Hz), 2.02 (m, 2H) ppm.
As the paragraph descriping shows that 108-55-4 is playing an increasingly important role.
Reference£º
Article; Guariento, Sara; Karawajczyk, Anna; Bull, James A.; Marchini, Gessica; Bielska, Martyna; Iwanowa, Xenia; Bruno, Olga; Fossa, Paola; Giordanetto, Fabrizio; Bioorganic and Medicinal Chemistry Letters; vol. 27; 1; (2017); p. 24 – 29;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics