1245724-46-2, (S)-Tetrahydro-2H-pyran-3-amine hydrochloride is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
(3S)-Tetrahydro-2H-pyran-3-amine hydrochloride (1.99 g, 14.5 mmol) in MeCN (10 ml) was added dropwise to a mixture of DIPEA (6.30 ml, 36.2 mmol) and ethyl 2,4- dichloropyrimidine-5-carboxylate (3.2 g, 14.5 mmol) in MeCN (60 ml) at 0C over a period of 5 minutes under air. The reaction mixture was stirred for 4 h, slowly allowing to warm to rt as the ice bath melted. The reaction mixture was stirred at rt for 18 h. The reaction mixture was evaporated to dryness to remove MeCN, diluted with EtOAc (100 mL), and washed with water then sat. brine. The organic layer was dried over MgS04, filtered and evaporated to afford crude product. The crude product was purified by fee, eluting with 0 – 40% EtOAc in heptane to afford the title compound (3.24 g, 78%) as a yellow oil;lH NMR (400 MHz, DMSO) 1.32 (3H, t), 1.49 – 1.6 (1H, m), 1.63 – 1.79 (2H, m), 1.83 – 1.94 (1H, m), 3.48 (1H, dd), 3.54 – 3.65 (2H, m), 3.74 (1H, dd), 4.08 – 4.19 (1H, m), 4.33 (2H, q), 8.57 (1H, d), 8.64 (1H, s); m/z [M-H]-284.
As the paragraph descriping shows that 1245724-46-2 is playing an increasingly important role.
Reference£º
Patent; ASTRAZENECA AB; CANCER RESEARCH TECHNOLOGY LIMITED; FINLAY, Maurice, Raymond, Verschoyle; GOLDBERG, Frederick, Woolf; TING, Attilla, Kuan, Tsuei; (103 pag.)WO2018/114999; (2018); A1;,
Tetrahydropyran – Wikipedia
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