951127-25-6, tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
70 f (1.78 g, 3.2 mmol) was dissolved in N,N-dimethylacetamide (10 mL)Intermediate 1 (1.15 g, 3.52 mmol) was added and reacted at room temperature for 30 min.The reaction system was cooled to 0 C, Sodium borohydrophosphate (1.37 g, 6.24 mmol) was added, reacted for 30 minutes, The reaction was continued at room temperature for 2 hours. The reaction solution was cooled to 0 C, water (40 mL) was added in that order, aqueous ammonia (5 mL) was added to adjust the pH to 9, and the solid was washed with water (50 mL x 3). The solid was dissolved in dichloromethane, dichloromethane ), The organic phase was combined, washed with saturated brine solution (50 mL), dried over anhydrous sodium sulfate, filtered, the filtrate was concentrated, and purified by silica gel column chromatography (dichloromethane / methanol (v / v) = 20: 1) ,A 70 g (1.15 g, yield 85%) of a white solid was obtained.
The synthetic route of 951127-25-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Sichuan Haisco Pharmaceutical Co.,Ltd.; FAN, JIANG; ZHANG, CHEN; PENG, FEI; WU, YE; FENG, JIANCHUAN; WANG, JIANMIN; ZHENG, SUXIN; WEI, YONGGANG; YE, FEI; (350 pag.)TW2017/8220; (2017); A;,
Tetrahydropyran – Wikipedia
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