125552-89-8, 4-(Bromomethyl)tetrahydropyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
4-oxo-5- (p-tolyl) -1,4-dihydropyridazine-3-carboxylic acid ethyl ester hydrochloride (4.2 g, 14.3 mmol, 1.0 eq) was dissolved in DMF (30 mL), Potassium carbonate (7.88 g, 57.2 mmol, 4.0 eq) and 4- (bromomethyl) tetrahydro-2H-pyran (3.06 g, 17.1 mmol, 1.2 eq) were added, and the reaction was heated to 50 C with stirring for 5 hours. The reaction was detected by LC-MS. The insoluble matter was removed by suction filtration. The filtrate was concentrated.The crude product was purified by silica gel column chromatography (100-200 mesh silica gel, EA / PE = 10-50%), and then recrystallized with a mixed solvent of DCM and MTBE (1:10) to obtain the product (1.6 g, yield: 32% ).
125552-89-8 4-(Bromomethyl)tetrahydropyran 2773286, aTetrahydropyrans compound, is more and more widely used in various.
Reference£º
Patent; Nanjing Yaojie Good Health Biological Technology Co., Ltd.; Wu Yongqian; Li Lin; Wan Zhonghui; (107 pag.)CN110041316; (2019); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics