127956-11-0, Methyl 4-oxotetrahydro-2H-pyran-3-carboxylate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Into a 250-mL round-bottom flask, was placed a mixture of methyl 4-oxo-tetrahydro-2H- pyran-3-carhoxylate (564 g, 3569 mmoi, 100 eq.), toluene (100 mL), ethane-1,2-diol (4.43g. 71.39mmol, 2.0 eq.),p.-TsOH (615 mg. 3.57 mmol, 0.10 eq.). The resulting mixture was allowed to stir for24 h with refiux under a dean stark trap. The mixture was concentrated and the residue was puiitied by a silica gel column eluted with 20%ethyl acetate/petroleum ether to afford methyl 1,4,8- trioxaspiro[4.5]decane-6-carboxylate as a colorless oil (6.7 g, 93%). LCMS (ES) [M+1] m/z 203.1.
As the paragraph descriping shows that 127956-11-0 is playing an increasingly important role.
Reference£º
Patent; GLOBAL BLOOD THERAPEUTICS, INC.; YU, Ming; LI, Zhe; (206 pag.)WO2018/119208; (2018); A1;,
Tetrahydropyran – Wikipedia
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