85064-61-5, Tetrahydropyranyl-4-acetic acid is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 1: N-[6-(4-Morpholinyl)-3-pyridinyl]-2-(tetrahydro-2H-pyran-4-yl)-N-[(1-(at)[4- (trifluoromethyl)phenyl]methyl)-4-piperidinyl)methyl]acetamide; Oxalyl chloride (0.27ml, 3.05mmol) was added to a stirred solution of tetrahydro-2H- pyran-4-ylacetic acid (0.2g, 1.38mmol) in DCM (10ml). DMF (1 drop) was added and the reaction mixture stirred at room temperature for 1.5h then evaporated in vacuo to afford a colourless oil (1.17g). The crude acid chloride was dissolved in DCM (10ml) and added to a stirred solution of 6-(4-morpholinyl)-N-[(1-{[4-(trifluoromethyl)phenyl]methyl)-4- piperidinyl) methyl]-3-pyridinamine D5 (0.45g, 1.03mmol) and triethylamine (0.58ml, 4.12mmol) in DCM (10ml). After 24h the mixture was washed with saturated sodium hydrogen carbonate, the organic layer separated by passage through a phase separation cartridge and evaporated in vacuo. Chromatography on silica gel eluting with 50-100% ethyl acetate in pentane gradient afforded the title compound as an orange gum (0.47g). A 70mg portion was dissolved in 1:1 DMSO/MeCN (0.9ml) and purified by mass directed autoprep hplc on a Waters C18 5muM column 8(id 19 x 100mm) eluting with 5 – 99% MeCN in water gradient containing 0.1 % formic acid. Fractions containing the desired material were passed through a 2g SCX column, the column washed with methanol (30ml) and eluted with 1 N ammonia in methanol to afford the title compound as a colourless gum (0.05g). Mass Spectrum (AP+): Found 561 (MH+). C30H39F3N403 requires 560.
The synthetic route of 85064-61-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GLAXO GROUP LIMITED; WO2005/103038; (2005); A1;,
Tetrahydropyran – Wikipedia
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