101691-94-5, 4-(Iodomethyl)tetrahydro-2H-pyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
2-(2,6-dichlorophenyl)-1 -[(1 S)-4-iodo-1-methyl-1 ,3-dihydro-2H-isoindol-2-yl]ethanone a48(100 mg, 0.22 mmol), sodium metabisulfite (87 mg, 0.45 mmol), tetrabutylammonium bromide (80 mg, 0.25 mmol), sodium formate (34 mg, 0.49 mmol), palladium(Il) acetate (5mg, 0.02 mmol), 1,10-phenanthroline (12 mg, 0.07 mmol) and triphenylphosphine (18 mg, 0.07 mmol) were mixed in DMSO (2 mL). The mixture was stirred at 70 C for 2 h. The reaction mixture was cooled to rt, then 4-(iodomethyl)tetrahydro-2H-pyran (100 mg, 0.44mmol) was added. The mixture was stirred at ft for 16 h, then diluted with DCM (50 mL) and successively washed with water (50 mL) and brine (50 mL). The organic layer was dried over MgSO4, filtered and concentrated under vacuum. The residue was purified by reverse phase chromatography (basic mode, LCMS prep) to yield 12 mg of 2-(2,6- dichlorophenyl)-1 -{(1 S)-1 -methyl-4-[(tetrahydro-2H-pyran-4-ylmethyl)sulfonyl]- 1 ,3-dihydro-2H-isoindol-2-yl}ethanone 42 as a white solid.Yield: 10%.LCMS (ES) 482/484/486 (M-?-H), 96.78 % purity.
101691-94-5, As the paragraph descriping shows that 101691-94-5 is playing an increasingly important role.
Reference£º
Patent; UCB BIOPHARMA SPRL; SKOLC, David; ATES, Ali; JNOFF, Eric; VALADE, Anne; (99 pag.)WO2016/55482; (2016); A1;,
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