14774-37-9, Tetrahydropyran-4-methanol is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Intermediate 077 N-(2,4-Dimethoxybenzyl)-5-nitro-2-(tetrahydro-2H-pyran-4- ylmethoxy)benzenesulfonamide 2-Chloro-N-(2,4-dimethoxybenzyl)-5-nitrobenzenesulfonamide (2.00 g, 5.17 mmol) was dissolved in dimethylformamide (10 mL), treated with tetrahydro-2H-pyran-4-ylmethanol (901 mg, 7.76 mmol) and sodium hydride (1.58 g, 36.2 mmoL) and was stirred for 2 hours at room temperature. It was quenched under ice cooling with water/ethyl acetate. The phases were separated, the aqueous phase was three times reextracted with ethyl acetate and all organic phases were combined, dried and concentrated in vacuo. It was tehn stirres with ethyl acetate/methyl tert.-butyl ether (1/2) until a white solid precipitated. Filtration led to N-(2,4-dimethoxybenzyl)-5-nitro-2-(tetrahydro-2H-pyran-4- ylmethoxy)benzenesulfonamide (2.20 g, 4.75 mmol, 91% yield, 95% purity) LC-MS (Method A): Rt = 1.16 min MS (ESIneg): m/z = 465 (M-H)+ 1H-NMR (400MHz, DMSO-d6) [ppm]: 1.23 – 1.36 (m, 2H), 1.70 – 1.77 (m, 2H), 2.09 – 2.23 (m, 1H), 3.29 – 3.39 (m, 2H), 3.59 (s, 3H), 3.65 (s, 3H), 3.89 (dd, 2H), 3.99 (d, 2H), 4.08 (s, 2H), 6.21 (d, 1H), 6.30 (dd, 1H), 7.01 (d, 1H), 7.25 (d, 1H), 7.42 (s, 1H), 8.23 (d, 1H), 8.31 (dd, 1H)., 14774-37-9
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Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; WERNER, Stefan; MESCH, Stefanie; BRAeUER, Nico; POOK, Elisabeth; DAHLLOeF, Henrik; NUBBEMEYER, Reinhard; OSMERS, Maren; KALTHOF, Bernd; (386 pag.)WO2016/198374; (2016); A1;,
Tetrahydropyran – Wikipedia
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