With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1172623-99-2,tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-hydroxytetrahydro-2H-pyran-3-yl)carbamate,as a common compound, the synthetic route is as follows.
9.53 g, 35.03 mmol) was dissolved in dichloromethane (130 mL) and reduced to 10 C to 0 C. The Dayton Martin oxidant (29.72 g, 70.06 mm0l) was added in part to the reaction solution. And the reaction was carried out at room temperature for 4 hours. Cooled to 0 C, saturated sodium bicarbonate solution (60 mL) was added dropwise to the reaction solution, stirred for 20 minutes, filtered, the filtrate was The organic phase was washed with saturated sodium bicarbonate solution (30 mL x 2). The organic phase was dried over anhydrous sodium sulfate 15, and the mixture was filtered and the residue was filtered through a solution of sodium tert-butyl sulfate (60 mL x 3) (Nu / nu) = 10: 1-4: 1) to give a white crystalline powder lI (l0.85 g, yield 94.7%)., 1172623-99-2
1172623-99-2 tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-hydroxytetrahydro-2H-pyran-3-yl)carbamate 86713019, aTetrahydropyrans compound, is more and more widely used in various.
Reference£º
Patent; SICHUAN HAISCO PHARMACEUTICAL CO., LTD; ZHANG, CHEN; FAN, JIANG; LI, CAI-HU; WEI, YONG-GANG; (99 pag.)TW2017/8222; (2017); A;,
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