1197-66-6, 2,2,6,6-Tetramethyl-2H-3,5,6-trihydropyran-4-one is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step I 2,2,6,6TetrarnethyI-4rirnethyIsiIany1ethynyI4etrahydropyranoL To a solution ofctlnrnl4rirnethyl-cilanc 5 5 mL 3e 4 rnrnol) in dr) 11W (2S rnL)as added n-BuLi (32 mL, 38.4 mmol) at -78 C and the mixture was stirred at that temperature for 45 nun followed by addition of 2,2,6,6-tetramcthyl-tetrahydro-pyran4-one (5.0 g, 32 mmoi) in dry THF (25 mL) at -78 C. The mixture was stirred for I h and then quenched with saturated NH4C1 solution and extracted with ethyl acetate (3 x 100 mL). Thecombined organic extract was washed with water and brine solution, dried over Na2SO4, filtered, and concentrated under reduced pressure to afford the product as sticky white sohd. Crude product was forwarded for next stage without purification. Yield: 8.0 g, crude., 1197-66-6
The synthetic route of 1197-66-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; JANSSEN PHARMACEUTICA NV; BAKTHAVATCHALAM, Rajagopal; AHMAD, Ishtiyaque; BATTULA, Sivaramakrishna; GIJSEN, Henricus Jacobus Maria; VADIVELU, Saravanan; WALL, Mark; WO2015/23289; (2015); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics