Day: September 8, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1194-16-7,2,2-Dimethyltetrahydropyran-4-one,as a common compound, the synthetic route is as follows.

[00660] Synthesis of compound 112.2. Into a 100-mL 3-necked round-bottom flask under nitrogen were added compound 112.1 (3 g, 23.41 mmol, 1.00 equiv), ethyl 2-cyanoacetate (2.9 g, 25.64 mmol, 1.10 equiv), S (3.0 g) and morpholine (0.75 g) in 50 mL of dry ethanol. The resulting mixture was stirred overnight at 50 C. Upon completion of the reaction solvent was removed under vacuum and crude was purified via flash column chromatography to afford 5.6 g (94%) of compound 112.2 as a yellow solid., 1194-16-7

The synthetic route of 1194-16-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NIMBUS IRIS, INC.; CHAUDHARY, Divya; KAPELLER-LIBERMANN, Rosana; WO2014/194242; (2014); A2;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.101691-94-5,4-(Iodomethyl)tetrahydro-2H-pyran,as a common compound, the synthetic route is as follows.

Step 3 [0341] 4-(Iodomethyl)tetrahydro-2H-pyran obtained in Step 2 (0.940 g, 4.16 mmol) was dissolved in acetonitrile (10 mL), triphenylphosphine (1.09 g, 4.16 mmol) was added thereto, and the mixture was stirred for 13 hours under reflux with heating. The solvent in the reaction mixture was evaporated under reduced pressure, diethyl ether was added to the residue, and the precipitated crystal was collected by filtration, whereby triphenyl[(tetrahydro-2H-pyran-4-yl)methyl]phosphonium iodide (0.600 g, 30%) was obtained. 1H NMR (300 MHz, DMSO-d6, delta): 7.90-7.74 (m, 15H), 3.68-3.61 (m, 4H), 3.16-3.13 (m, 2H), 2.02-1.91 (m, 1H), 1.41-1.31 (m, 4H)., 101691-94-5

The synthetic route of 101691-94-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Kyowa Hakko Kirin Co., Ltd.; FURUTA, Takayuki; SAWADA, Takashi; DANJO, Tomohiro; NAKAJIMA, Takahiro; UESAKA, Noriaki; EP2881394; (2015); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.156002-64-1,Methyl 2-(tetrahydro-2H-pyran-4-yl)acetate,as a common compound, the synthetic route is as follows.

Sodium hydroxide (16 g) in water (400 mi) was added to a solution of Intermediate 27 (13 g) in MeOH (60 ML). The mixture was stirred overnight at room temperature, then evaporated in vacuo. The solution was washed with Et2O (50 ml), acidified with concentrated hydrochloric acid to pH 2 and extracted with EtOAc (100 ML), the solvent washed with brine (50 ML), dried (MGS04) and evaporated to give the title compound as a colourless solid (10.2 g). MS 144 (M), 156002-64-1

As the paragraph descriping shows that 156002-64-1 is playing an increasingly important role.

Reference£º
Patent; CELLTECH R & D LIMITED; WO2004/113298; (2004); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1228779-96-1,3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide,as a common compound, the synthetic route is as follows.

To the reaction flask was added 35 g of Ven-18 (80 mmol) and 1000 mL of dichloromethane, 22.8 g of Ven-21(80 mmol), 17.7 g of DMAP (160 mmol) and 27.8 g (160 mmol) of EDCI at 30 C for about 24 hours.Should be completely followed by 900 mL of 10% aqueous acetic acid, 900 mL of saturated aqueous sodium bicarbonate, 900 mL of water, 900 mL of saturated foodWashed with brine, dried over anhydrous sodium sulfate and concentrated to dryness to give a crude product (56 g) as a yellow solid. The crude product was recrystallized from 1000 mL of acetonitrile,Filtration, filter cake 200mL acetonitrile washing, drying yellow powdery solid 47g, the yield of 80%. HPLC purity: 99%.

1228779-96-1, As the paragraph descriping shows that 1228779-96-1 is playing an increasingly important role.

Reference£º
Patent; Hangzhou Keyao Pharmaceutical Technology Co., Ltd.; Zhou Junming; (10 pag.)CN107089981; (2017); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1172623-99-2,tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-hydroxytetrahydro-2H-pyran-3-yl)carbamate,as a common compound, the synthetic route is as follows.

Step 0: tert-Butyl [(2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pvran-3 -yflcarbamateTo 46.8 kg (142 mol) of tert-butyl [(2R,35)-2-(2,5-difluorophenyl)-5-hydroxytetrahydro- 2H-pyran-3-yl]carbamate in a stirred vessel was added acetonitrile (150 kg), acetic acid (50 kg), and water (25 kg). After dissolving at room temperature, the solution was cooled to 0 C and RuC13?3H20 (250 g, 956 mmol) in water (50 kg) was added under nitrogen. Then, NaBrO3 (11.7kg, 77.5 mol) was added in six portions every 1 .5h under nitrogen. After stirring at 0 C for 6h,2-propanol (31 kg) was added over 30 mm. at 0 C. Then, water (720 kg) was added at this temperature over 5h. The resulting slurry was stirred overnight, filtered, and cake washed with water. The solids were then dried under vacuum at 40-60 C to give tert-butyl [(2R,35)-2-(2,5- difluorophenyl)-5-oxotetrahydro-2H-pyran-3 -yl]carbamate.

1172623-99-2, As the paragraph descriping shows that 1172623-99-2 is playing an increasingly important role.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; ARROYO, Itzia; KRUEGER, Davida; CHEN, Ping; MOMENT, Aaron; BIFTU, Tesfaye; SHEEN, Faye; ZHANG, Yanfeng; MERCK SHARPE & DOHME LTD.; WO2013/3249; (2013); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1098184-12-3,(S)-2-(((Benzyloxy)carbonyl)amino)-2-(tetrahydro-2H-pyran-4-yl)acetic acid,as a common compound, the synthetic route is as follows.

tert-Butyl(3S,8aR)-3-[(1R)-1,2,3,4-tetrahydronaphthalen-1-ylcarbamoyl]hexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate (380 mg) obtained in Example 5 (ii) was dissolved in 4M hydrogen chloride-ethyl acetate solution (5 mL), and the solution was stirred at room temperature for 18 hr. The precipitate resulting from the reaction mixture was collected by filtration. To the collected precipitate were added tetrahydrofuran (5 mL), N-ethyl-N-(1-methylethyl)propan-2-amine (0.497 mL), (2S)-{[(benzyloxy)carbonyl]amino}(tetrahydro-2H-pyran-4-yl)ethanoic acid (418 mg) and 1-hydroxybenzotriazole (218 mg). To this mixture was added 1-ethyl-3-3-dimethylaminopropyl)carbodiimide hydrochloride (310 mg), and the mixture was stirred at room temperature for 18 hr. To the reaction mixture was added water (50 mL), and the mixture was extracted with ethyl acetate (200 mL). The organic layer was washed with saturated brine (50 mL), dried over anhydrous magnesium sulfate, and filtered, and the filtrate was concentrated to give an oil. This oil (500 mg) was dissolved in methanol (3 mL), 20% palladium-carbon (100 mg, 20 wt %) was added thereto, and the mixture was stirred at room temperature for 4 hr under a hydrogen atmosphere (3 atm). The insoluble material was filtered off through a celite pad, and the filtrate was concentrated to give an oil., 1098184-12-3

1098184-12-3 (S)-2-(((Benzyloxy)carbonyl)amino)-2-(tetrahydro-2H-pyran-4-yl)acetic acid 66926961, aTetrahydropyrans compound, is more and more widely used in various.

Reference£º
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; US2011/34469; (2011); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

33821-94-2, 2-(3-Bromopropoxy)tetrahydro-2H-pyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a mixture of 4-iodo-1H-pyrazole (2.0 g, 10.3 mmol) and Cs CO(5.04 g, 15.5 mmol) in MeCN (28 mL) was added 2-(3-bromopropoxy)tetrahydro-2H-pyran ( 1.84 mL, 10.8 mmol) and the mixturestirred at T overnight. The crude reaction mixture was poured into water andextracted with EtOAc (x 3). The combined organic layers were washed withbrine, dried (MgSO4) and concentrated in vacuo. The resulting residue waspurified by FCC, using a gradient of 0-80% EtOAc in cyclohexane, to give thetitle compound (2.95 g, 81%)., 33821-94-2

The synthetic route of 33821-94-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CHIESI FARMACEUTICI S.P.A.; Alcaraz, Lilian; Panchal, Terry Aaron; Jennings, Andrew Stephen Robert; Cridland, Andrew Peter; Hurley, Christopher; (80 pag.)KR2016/16973; (2016); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

36838-71-8, 4-Methylenetetrahydro-2H-pyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1: 4-(9-Bora-bicyclo[3.3.1]non-9-ylmethyl)-tetrahydropyran A mixture of 4-methylene-tetrahydropyran (50 mg) and 9-bora-bicyclo[3.3.1]nonane (0.5 M solution in tetrahydrofuran, 1 mL) is stirred for 6 h at room temperature. The solution is used directly for the next step.

36838-71-8, As the paragraph descriping shows that 36838-71-8 is playing an increasingly important role.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ECKHARDT, Matthias; FRATTINI, Sara; LANGKOPF, Elke; WAGNER, Holger; US2014/163025; (2014); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

1768-64-5, 4-Chlorotetrahydropyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,1768-64-5

b) Formation of the Grignard reagent; An inerted 3 L 3-necked flask is charged with THF (50 mL) and magnesium turnings (9 g, 0.370 mol, 1.25 equiv. ). The mixture is heated to Tmass = 60C and iodine (0.150 g) and 4-chlorotetrahydropyran (1 mL) are added. Initiation is observed within 5 minutes. Then, the mixture is heated to Tmass = 63-68C and addition of remaining 4- chlorotetrahydropyran (39.19 mL diluted with 188 mL of THF) is performed over 1 hour keeping T mass constant at about 68C. After 40 minutes of post-agitation, the reaction mixture is allowed to cool to room temperature.

1768-64-5 4-Chlorotetrahydropyran 137202, aTetrahydropyrans compound, is more and more widely used in various.

Reference£º
Patent; ELI LILLY AND COMPANY; WO2005/47272; (2005); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

220641-87-2, N-Methyltetrahydro-2H-pyran-4-amine is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 24. Preparation of 5-chloro-3-isopropyl-N-methyl-N-(tetrahydro-2H-pyran-4-yl) pyrazolo[ 1 ,5-a]pyrimidin-7-amine [00201] Step 1: Synthesis of 5-chloro-3-isopropyl-N-methyl-N-(tetrahydro-2H-pyran- 4-yl) pyrazolo[l,5-a]pyrimidin-7-amine. A mixture of 5,7-dichloro-3- isopropylpyrazolo[l,5-a]pyrimidine (687 mg, 3.0 mmol), N-methyl-tetrahydro-2H-pyran-4- amine (414 mg, 3.6 mmol), and K2C03 (828 mg, 6.0 mmol) in 10 mL of acetonitrile was heated at reflux under N2 for 2 h., diluted with water (10 mL) and the mixture was extracted with EtOAc (15 mL X 3). The combined organic phases were dried over Na2S04, filtered and concentrated. The residue was purified by preparative TLC on silica gel (petroleum ether/EtOAc = 3/1) to afford 5-chloro-3-isopropyl- N-methyl-N-(tetrahydro-2H-pyran-4- yl)pyrazolo[l,5-a] pyrimidin-7- amine (813 mg, 88 % yield) as yellow solid. ESI-LCMS (m z): 309.1 [M+l]+., 220641-87-2

The synthetic route of 220641-87-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; EPIZYME, INC.; CHESWORTH, Richard; MORADEL, Oscar Miguel; SHAPIRO, Gideon; DUNCAN, Kenneth W.; MITCHELL, Lorna Helen; JIN, Lei; BABINE, Robert E.; WO2014/144455; (2014); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics