1768-64-5, 4-Chlorotetrahydropyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,1768-64-5
b) Formation of the Grignard reagent; An inerted 3 L 3-necked flask is charged with THF (50 mL) and magnesium turnings (9 g, 0.370 mol, 1.25 equiv. ). The mixture is heated to Tmass = 60C and iodine (0.150 g) and 4-chlorotetrahydropyran (1 mL) are added. Initiation is observed within 5 minutes. Then, the mixture is heated to Tmass = 63-68C and addition of remaining 4- chlorotetrahydropyran (39.19 mL diluted with 188 mL of THF) is performed over 1 hour keeping T mass constant at about 68C. After 40 minutes of post-agitation, the reaction mixture is allowed to cool to room temperature.
1768-64-5 4-Chlorotetrahydropyran 137202, aTetrahydropyrans compound, is more and more widely used in various.
Reference£º
Patent; ELI LILLY AND COMPANY; WO2005/47272; (2005); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics