220641-87-2, N-Methyltetrahydro-2H-pyran-4-amine is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 24. Preparation of 5-chloro-3-isopropyl-N-methyl-N-(tetrahydro-2H-pyran-4-yl) pyrazolo[ 1 ,5-a]pyrimidin-7-amine [00201] Step 1: Synthesis of 5-chloro-3-isopropyl-N-methyl-N-(tetrahydro-2H-pyran- 4-yl) pyrazolo[l,5-a]pyrimidin-7-amine. A mixture of 5,7-dichloro-3- isopropylpyrazolo[l,5-a]pyrimidine (687 mg, 3.0 mmol), N-methyl-tetrahydro-2H-pyran-4- amine (414 mg, 3.6 mmol), and K2C03 (828 mg, 6.0 mmol) in 10 mL of acetonitrile was heated at reflux under N2 for 2 h., diluted with water (10 mL) and the mixture was extracted with EtOAc (15 mL X 3). The combined organic phases were dried over Na2S04, filtered and concentrated. The residue was purified by preparative TLC on silica gel (petroleum ether/EtOAc = 3/1) to afford 5-chloro-3-isopropyl- N-methyl-N-(tetrahydro-2H-pyran-4- yl)pyrazolo[l,5-a] pyrimidin-7- amine (813 mg, 88 % yield) as yellow solid. ESI-LCMS (m z): 309.1 [M+l]+., 220641-87-2
The synthetic route of 220641-87-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; EPIZYME, INC.; CHESWORTH, Richard; MORADEL, Oscar Miguel; SHAPIRO, Gideon; DUNCAN, Kenneth W.; MITCHELL, Lorna Helen; JIN, Lei; BABINE, Robert E.; WO2014/144455; (2014); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics