4677-20-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4677-20-7,4-(2-Bromoethyl)tetrahydropyran,as a common compound, the synthetic route is as follows.
Intermediate 28: 2-(ButyloxyV8-(methyloxyV9-(2-{r2-(tetrahvdro-2H-pyran-4- yl)ethylloxy)ethyl)-9H-purin-6-amineTo 2-[6-amino-2-(butyloxy)-8-(methyloxy)-9H-purin-9-yl]ethanol (0.03 g, 0.107 mmol) in dry THF (3ml) was added potassium f-butoxide solution in THF (0.160 ml, 0.160 mmol) followed by 4-(2-bromoethyl)tetrahydro-2H-pyran (0.031 g, 0.160 mmol) in THF 2ml) and the resulting white suspension was heated at 500C for 18 hours then at 7O0C for 7 hours. Additional 4-(2-bromoethyl)tetrahydro-2H-pyran, (0.031 g, 0.160 mmol) and potassium f-butoxide solution in THF (0.160 ml, 0.160 mmol) were added and the mixture heated at 7O0C for 72 hours. The mixture was cooled and quenched with water (5ml), extracted with DCM (2x5ml), the organic phase was isolated by separation through a hydrophobic frit and evaporated. The sample was dissolved in 1 :1 MeOH:DMSO (1 ml) and purified by Mass Directed AutoPrep. The solvent was dried under a stream of nitrogen to give the title compound as a colourless gum (3.1 mg). LCMS: tRET = 2.17 min; MH+ 394
The synthetic route of 4677-20-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; CAMPOS, Sebastien, Andre; COE, Diane, Mary; SMITH, Stephen, Allan; TRIVEDI, Naimisha; WO2010/18132; (2010); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics