With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.85064-61-5,Tetrahydropyranyl-4-acetic acid,as a common compound, the synthetic route is as follows.,85064-61-5
General procedure: To (1 S, 1 ‘S)-l , 1 ‘-(5,5’-([ 1, 1 ‘-biphenyl]-4,4’-diyl)bis(lH-imidazole-5,2- diyl))bis(2,2-dimethylpropan- 1 -amine) tetrahydrochloride (75 mg, 0.124 mmol) was added 3-hydroxy-2,2,3-trimethylbutanoic acid (38.2 mg, 0.261 mmol) in DMF (3 mL) followed by DIPEA (0.174 mL, 0.996 mmol) at 0 ¡ãC. Then HATU (97 mg, 0.255 mmol) was added and stirred from 0 ¡ãC to RT for 6 h. The crude was dissolved in EtOAc (50 mL), washed with saturated NH4C1 (25 mL), 10percent NaHC03(25 mL), brine (25 mL), dried over Na2S04and concentrated under reduced pressure. The crude material was purified by reverse phase HPLC (ACN/water/TFA) to getTFA salt of Example B-69 (30 mg) as a white solid. HPLC (Condition B-1 and B-2): > 97percent homogeneity index. LC/MS (Condition B-12): Rt= 2.13 min.XH NMR (MeOD, 5 = 3.34 ppm, 400 MHz): delta 7.92-7.85 (m, 10 H), 4.94 (s, 2 H), 1.28 (s, 18 H), 1.16 (s, 12 H), 1.15 (s, 12 H). LC/MS: Anal. Calcd. for [M+H]+C42H61N604: 713.47; found 713.3
85064-61-5 Tetrahydropyranyl-4-acetic acid 2773575, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; HEWAWASAM, Piyasena; LOPEZ, Omar D.; TU, Yong; WANG, Alan Xiangdong; XU, Ningning; KADOW, John F.; MEANWELL, Nicholas A.; GUPTA, Samayamunthula Venkata Satya Arun Kumar; KUMAR, Indasi J. Gopi; PUNUGUPATI, Suresh Kumar; BELEMA, Makonen; WO2015/5901; (2015); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics