With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.344329-76-6,Tetrahydro-2H-pyran-4-carboxamide,as a common compound, the synthetic route is as follows.
Preparation 111; C- (Tetrahvdro-pyran)-metvlamine; In a 2L flask, charge tetrahydro-pyran-4-carboxylic acid amide (51g, 0. 395mol) and THF (1. 3L) and cool the reaction in an ice-bath. Add LAH (30g, 0.791) portion-wise. Stir the reaction at 10¡ãC for 16 hours and quench by the drop-wise addition of DI water (30ml), 15percent NaOH (30ml), and DI water (90mol). Stir the reaction at ambient temperature for 16 hours. Filter the salts and concentrate the filtrate under vacuum to give 36.79g clear oil of the title compound.
344329-76-6, The synthetic route of 344329-76-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ELI LILLY AND COMPANY; WO2005/66126; (2005); A1;,
Tetrahydropyran – Wikipedia
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