1194-16-7, 2,2-Dimethyltetrahydropyran-4-one is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
In a 50 mL round bottomed flask, 2,2-dimethyldihydro-2/-/-pyran-4(3/7)-one (0.3 g, 2.3 mmol) was dissolved in water (15 mL) along with sodium metabisulfite (0.22 g, 1.17 mmol). The mixture was allowed to stir at rt for 1 h and N1-benzyl-N1-isopentyl-N2-methylethane-1,2-diamine dihydrochloride (0.72 g, 2.3 mmol) and DIPEA (1.6 mL, 9.4 mmol) were added. The mixture was stirred for 2 h and potassium cyanide (0.243 g, 3.7 mmol) was added to the reaction mixture. The reaction was stirred at rt until full conversion was achieved (12 days). The colourless solution was extracted with ethyl acetate and the combined organic phases were washed with NaHCC>3, dried over MgSC>4, filtered and concentrated to dryness to give the title compound as yellow oil (0.65 g, yield 75%). 1H NMR (400 MHz, CDCl3) delta ppm: 7.41 – 7.13 (m, 5H), 3.83 – 3.77 (m, 2H), 3.58 (s, 2H), 2.61 – 2.41 (m, 4H), 2.23 (s, 3H), 2.02 – 1.93 (m, 2H), 1.69 – 1.51 (m, 5H), 1.49 – 1.39 (m, 2H), 1.38 (s, 3H), 1.23 (s, 3H), 0.86 (d, J = 6.6 Hz, 6H)
1194-16-7, As the paragraph descriping shows that 1194-16-7 is playing an increasingly important role.
Reference£º
Patent; LABORATORIOS DEL DR. ESTEVE, S.A.; ALMANSA-ROSALES, Carmen; GARCIA-LOPEZ, Monica; RODRIGUEZ ESCRICH, Sergio; (158 pag.)WO2018/153546; (2018); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics