With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5631-96-9,2-(2-Chloroethoxy)tetrahydro-2H-pyran,as a common compound, the synthetic route is as follows.
EXAMPLE 1 LL- (4- [2- (2-HYDROXYETHOXY) ETHYL]-L- piperazinyl) dibenzo (b, f] [1, 4] thiazepine (base Quetiapine) To 26.2 mL of 50% aqueous solution of sodium hydroxide are added successively 5 G (14.7 mmols) de 2- (4- dibenzo [b, f] [1, 4] THIAZEPINE-11-IL-PIPERAZINE-L-IL) ethanol, 10.43 g (63.4 mmols) of 2- (2-CHLOROETHOXY)-TETRAHYDRO-2H- pyrane and 0. 49 g of tetrabutyl ammonium hydrogen sulphate. The mixture is heated at 60C for 6 hours with thorough stirring. It is cooled to 20-25C, and 45 mL de toluene and 26 mL of water are added while agitating. The phases are separated and the organic phase is washed with water (2 x 26 ML). 32 mL of water and 5 mL of 35% hydrochloric acid 35% are added and the two-phase mixture is stirred at 20-25C for 3 hours. The phases are separated and the aqueous phase is washed successively with n-butanol (10 mL) and toluene (10 ML). Then 45 ML OF toluene and 10% aqueous solution of potassium carbonate are added until the aqueous phase pH 10 is reached. The phases are separated and the aqueous phase is extracted with toluene (10 mL). The combined organic phases are evaporated to dryness under vacuum, yielding 4.80 g (85%) of the product of the title as a light yellow oil., 5631-96-9
As the paragraph descriping shows that 5631-96-9 is playing an increasingly important role.
Reference£º
Patent; LABORATORIOS VITA, S.A.; WO2005/14590; (2005); A2;,
Tetrahydropyran – Wikipedia
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