With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2081-44-9,Tetrahydro-2H-pyran-4-ol,as a common compound, the synthetic route is as follows.
A. 4-(4-methylphenylsuIfonyloxy)tetrahydropyran: Add TsCl (22.33 g, 117.1 mmol) and DMAP (0.55 g, 4.5 mmol) to a mixture of 4-hydroxytetrahydropyran (9.2 g, 90.08 mmol), pyridine (10.93 ml, 135.12 mmol), and methylene chloride (180 ml). Stir the mixture for 7 days, then add hexanes (360 ml), and filter. Collect the filtrate and wash it sequentially with 5N HCl, and brine. Dry over MgSC>4, remove the solids by filtration and concentrate the filtrate Purify by silica gel chromatography (5-30% methylene chloride/hex) to give the product as an oil (20.75 90%). 1HNMR (CDCl3): delta 1.70-1.91 (m, 4H), 2.47 (s, 3H), 3.48 (m, 2H), 3.86 (m, 2H), 4.65 (m, IH), 7.35 (d, 2H, 8.8 Hz), 7.80 (d, 2H, 8.8 Hz).
2081-44-9, As the paragraph descriping shows that 2081-44-9 is playing an increasingly important role.
Reference£º
Patent; ELI LILLY AND COMPANY; WO2007/87488; (2007); A2;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics