With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.344329-76-6,Tetrahydro-2H-pyran-4-carboxamide,as a common compound, the synthetic route is as follows.
Example 7 A solution of Example B5 (0.090 g, 0.697 mmol) in DCE (3 mL) was treated with oxalyl chloride (0.122 mL, 1.394 mmol), heated at 80¡ã C. for 3 h, cooled to RT and concentrated to dryness. The solid was treated with a solution of Example A4 (0.09 g, 0.348 mmol) and TEA (0.194 mL, 1.394 mmol) in THF (3 mL) and stirred at RT for 2 h. The mixture was treated with satd. NaHCO3, extracted with EtOAc (2*) and the combined organics were washed with brine, dried over Na2SO4, concentrated to dryness and purified via silica gel chromatography (MeOH/DCM) to afford N-((5-((2-acetamidopyridin-4-yl)oxy)-6-methylpyridin-2-yl)carbamoyl)tetrahydro-2H-pyran-4-carboxamide (44 mg, 31percent) as a white solid. 1H NMR (400 MHz, DMSO-d6): delta 10.99 (s, 1H), 10.86 (s, 1H), 10.54 (s, 1H), 8.16 (d, J=5.7 Hz, 1H), 7.89 (d, J=8.8 Hz, 1H), 7.60 (d, J=8.8 Hz, 1H), 7.57 (d, J=2.3 Hz, 1H), 6.61 (dd, J=5.7, 2.5 Hz, 1H), 3.87 (m, 2H), 3.32-3.25 (m, 2H), 2.68 (m, 1H), 2.21 (s, 3H), 2.01 (s, 3H), 1.71 (m, 2H), 1.66-1.54 (m, 2H); MS (ESI) m/z: 414.2 (M+H+)., 344329-76-6
344329-76-6 Tetrahydro-2H-pyran-4-carboxamide 13197203, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; Deciphera Pharmaceuticals, LLC; Flynn, Daniel L.; Caldwell, Timothy Malcolm; Samarakoon, Thiwanka; Vogeti, Lakshminarayana; Kaufman, Michael D.; Patt, William C.; Ahn, YuMi; US2014/275016; (2014); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics