With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1197-66-6,2,2,6,6-Tetramethyl-2H-3,5,6-trihydropyran-4-one,as a common compound, the synthetic route is as follows.
Step I, i-(4-hydroxy2,2,6,64etrameihyItetrahydro4Hpyran-4y1)eihanone: To astirred solution of ethoyethene (184 g, 25.5 mmol) in THE (40 mE) was added t8J (16rnL, 25.6 mmoi) at -78 C. The reaction mixture was slowly allowed to warm to 10 Cfollowed by addition of 2 ,2,6,6-tetramethyldihydro-2H–pyran-4(3 [1)-one (2 g, 1 2.8 mmol).The mixture was stirred for 16 h at room temperature. The reaction was quenched by theaddition of HCI (3 mL) in aqueous methanol (20 mL, MeOR 1:1). The combined organic extracts were washed with brine, dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure to provide the crude title compound as an off-white sob ci (1 .2 g) which was used in the next step without further purification., 1197-66-6
As the paragraph descriping shows that 1197-66-6 is playing an increasingly important role.
Reference£º
Patent; JANSSEN PHARMACEUTICA NV; BAKTHAVATCHALAM, Rajagopal; AHMAD, Ishtiyaque; BATTULA, Sivaramakrishna; GIJSEN, Henricus Jacobus Maria; VADIVELU, Saravanan; WALL, Mark; WO2015/23289; (2015); A1;,
Tetrahydropyran – Wikipedia
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