25637-16-5, 4-Bromotetrahydropyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 1384-[4-(2-methoxyphenyl)piperazin- I -yl]-1 -(tetrahydro-2H-pyran-4-yl)- I Hpyrazolo[ 3, 4-d]pyrimidine To 100 mg (0.32 mmo[) 4-[4-(2-methoxypheny[)piperazin-1 -y[]-1 H-pyrazo[o[3,4- d]pyrimidine, 525mg (1.61 mmo[) cesium carbonate and 12.3 mg (0.08 mmo[) sodium iodide in 4 mL anhydrous DMF were added 160 mg (0.97 mmo[) 4-bromotetrahydro- 2H-pyran. It was stirred over night at rt and then 4 h at 50CC. The mixture was concentrated on a rotavap. 20 mL water and 15 mL dich[oromethane were added.The [ayers were separated and the aqueous phase was extracted three times with dich[oromethane. The combined organic phases were washed with brine, dried over magnesium su[fate and concentrated. The residue was purified by HPLC yie[ding 44 mg (34%) product.LC-MS (ana[ytica[ method 3): R = 1.14 mm, MS (ESipos): mlz = 395 (M+H).1H-NMR (300MHz, DMSO-d6): 6 [ppm]= 1.76 – 1.87 (m, 2H), 2.05 – 2.22 (m, 2H), 3.05 -3.14 (m, 4H), 3.47 – 3.60 (m, 2H), 3.82 (5, 3H), 3.94 – 4.03 (m, 2H), 4.03 – 4.11 (m,4H), 4.85 -4.99 (m, 1H), 6.84- 7.03 (m, 4H), 8.28 (5, 1H), 8.33 – 8.38 (m, 1H)., 25637-16-5
25637-16-5 4-Bromotetrahydropyran 13349654, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; HEISLER, Iring; MUeLLER, Thomas; GOLZ, Stefan; TELSER, Joachim; REHWINKEL, Hartmut; SIEBENEICHER, Holger; BUCHMANN, Bernd; ZORN, Ludwig; EIS, Knut; KOPPITZ, Marcus; LINDNER, Niels; HEROULT, Melanie; NEUHAUS, Roland; WO2013/182612; (2013); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics