With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14774-36-8,(Tetrahydropyran-3-yl)methanol,as a common compound, the synthetic route is as follows.
Intermediate 13: 3-(Bromomethyl)tetrahvdro-2H-pyranTo tetrahydro-2H-pyran-3-ylmethanol (1g) in dry dichloromethane (28 ml) at 0C and under nitrogen, was added triethylamine (2.7 ml) in one go, followed by methanesulphonyl chloride (0.87 ml) dropwise over 1 minute. The reaction was allowed to warm to room temperature and left at this temperature overnight. The reaction mixture was diluted with dichloromethane (20 ml) and washed with saturated aqueous sodium bicarbonate (20 ml). The organic layer was passed through a hydrophobic frit to dry and concentrated in vacuo to yield a yellow oil., 14774-36-8
14774-36-8 (Tetrahydropyran-3-yl)methanol 85769, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2008/101867; (2008); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics