1228779-96-1, 3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Add Intermediate V4 (36.2g, 47mmol, 1.0eq) to the 1000mL reaction flask,Intermediate VM4 (22.3g, 71mmol, 1.5eq) and 600mL dichloromethane,Stir to dissolve, then add DCC (17.4g, 85mmol, 1.8eq) and 3.6g DMAP, warm to 30-35 reaction, TLC monitor the reaction.After the reaction was completed, 400 mL of 10% acetic acid aqueous solution was added and stirred for 30 min to separate the organic phase. The organic phase was washed with saturated aqueous sodium bicarbonate solution (300 mL ¡Á 1), saturated aqueous sodium chloride solution (300 mL ¡Á 1) and dried over anhydrous sodium sulfate. Filter with suction and concentrate the filtrate under reduced pressure to obtain a crude solid. This crude product was recrystallized with 500 mL of ethyl acetate and n-hexane (1: 1) to obtain 44.1 g of solid product V5. Yield: 89%., 1228779-96-1
The synthetic route of 1228779-96-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Nantong Changyou Pharmaceutical Technology Co., Ltd.; Li Zebiao; Chen Dan; Wu Hongdang; Xu Xiaohong; Lin Yanfeng; (9 pag.)CN110878098; (2020); A;,
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