33821-94-2, 2-(3-Bromopropoxy)tetrahydro-2H-pyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a flask containing (S)-(but-3-yn-2-yloxy)(tert-butyl)dimethylsilane 34 (2.21 g, 12 mmol) in dry THF (40 mL) was added dropwise at -30 C a solution of n-BuLi (1.6 M in hexanes, 7.5 mL, 12 mmol) and the mixture was stirred for 30 min. The reaction mixture was cooled to -78 C, dry HMPA (5 mL) was added and the solution stirred for 15 min. Then a solution of 2-(3-bromopropoxy)tetrahydro-2H-pyran (2.54 g, 11.4 mmol) in dry THF (10 mL) was added dropwise and the reaction mixture was allowed to warm to 23 C slowly. After 40 h, the reaction mixture was diluted with water (5 mL) and extracted with Et2O (4 ¡Á 25 mL). The combined organic extracts were washed with H2O (5 mL) and brine (5 mL), dried over MgSO4, filtered and the solvents removed under reduced pressure. The crude product was purified by column chromatography (pentane:Et2O 90:10) to give 35 (3.02 g, 81% yield). 1H NMR (400 MHz, 21 C, CDCl3): 4.61-4.56 (m, 1H), 4.54-4.45 (m, 1H), 3.92-3.76 (m, 2H), 3.55-3.41 (m, 2H), 2.36-2.24 (m, 2H), 1.88-1.66 (m, 4H), 1.64-1.46 (m, 4H), 1.37 (d, J 6.4, 3H), 0.90 (s, 9H), 0.11 (d, J 3.9, 6H)., 33821-94-2
The synthetic route of 33821-94-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Krief, Alain; Wouters, Johan; Norberg, Bernadette; Kremer, Adrian; Arkivoc; vol. 2018; 5; (2018); p. 308 – 333;,
Tetrahydropyran – Wikipedia
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