With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.116131-44-3,3-(Bromomethyl)tetrahydro-2H-pyran,as a common compound, the synthetic route is as follows.
In a 200 ml-capacity glass flask equipped with a stirring device, a thermometer, a reflux condenser and a dropping funnel, 11.39 g (47.8 mmol) of potassium 3-amino-N-(furan-2-yl)benzenesulfonamide, potassium carbonate 6.93 g (50. lmmol) and 60 ml of hydrazine, N-dimethylformamide were added under a nitrogen atmosphere. While stirring at room temperature, 8.99 g (50.2 mmol) of 3-methylbromo-tetrahydropyran was added, and the mixture was reacted at 70 to 80 C for 3 to 4 hours. After the reaction was completed, the mixture was cooled to room temperature, and then 200 ml of toluene was added. After washing twice with water (180 ml), it was dried over magnesium sulfate. After filtration, it was concentrated under reduced pressure. Then, the obtained yellow oil was purified by silica gel column chromatography (packing material: Wakogel C-200, eluent: hexane / ethyl acetate = 1/2 (volume ratio)). N-(furan-2-yl)-3-(((tetrahydro-2H-pyran-3-yl)methyl)amino)benzenesulfonamide 11.90 g (yield 74%), purity 99% Amino solids by area fraction of high performance liquid chromatography).
116131-44-3, 116131-44-3 3-(Bromomethyl)tetrahydro-2H-pyran 22617257, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; Liu Shuangwei; (6 pag.)CN108003144; (2018); A;,
Tetrahydropyran – Wikipedia
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