344329-76-6, Tetrahydro-2H-pyran-4-carboxamide is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 87 A^-[10,ll-dichloro-4-oxo-3-(trifluoromethyl)-2,5,7-triazatricyclo[6.4.0.02’6]dodeca- l(12),6,8,10-tetraen-3-yl]oxane-4-carboxamide (ABR 239441) To a stirred solution of oxane-4-carboxamide (500 mg, 3.87 mmol) in DMF (15 mL) was added pyridine (312 mu, 3.87 mmol) followed by ethyl 3,3,3-trifluoro-2-oxopropanoate (658 mg, 3.87 mmol) at room temperature under argon. The reaction mixture was stirred at room temperature for 1 h and then thionyl chloride (422 mu, 5.81 mmol) was added. The reaction was stirred for a further 16 h and was then concentrated. The acyl intermediate that remained was dissolved in DMF (5 mL) under argon. A solution of 5,6-dichloro-lH-l ,3-benzodiazol-2-amine (587 mg, 2.90 mmol) in DMF (7 mL) and triethylamine (861 mu, 6.19 mmol) were added and the reaction mixture was stirred at room temperature for 4 h. The reaction mixture was diluted with water (10 mL) and extracted with EtOAc (2 x 15 mL). The combined organic extracts were washed with brine, dried (MgSO^, filtered and concentrated. The crude product was purified by silica chromatography. Further purification was carried out by trituration in DCM/MeOH and then pentane to afford the title compound (20 mg, 1percent).
344329-76-6, The synthetic route of 344329-76-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ACTIVE BIOTECH AB; WELLMAR, Ulf; LIBERG, David; EKBLAD, Maria; BAINBRIDGE, Marie; EAST, Stephen; HARGRAVE, Jonathan; PREVOST, Natacha; WO2015/177367; (2015); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics