127956-11-0, Methyl 4-oxotetrahydro-2H-pyran-3-carboxylate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
2c (5.5g, 34.97mmol) and ammonium acetate (8.1g, 104.9mmol) in methanol (100mL) were stirred at room temperature overnight. The mixture was concentrated in vacuo, and diluted with water (50mL) and extracted with DCM (50mL¡Á3). The separated organic layer was dried over Na2SO4 and concentrated in vacuo. The resulting crude methyl 4-amino-5,6-dihydro-2H-pyran-3-carboxylate 3c was then dissolved in acetonitrile (50mL), and 2,2,2-trichloroacetyl isocyanate (7.2g, 38.46mmol) was added. The resulting mixture was stirred for 30min, and the precipitated solids were collected and dissolved in a solution of ammonia in methanol (10mL, 7N). Then the resulting mixture was heated at 70C for 1h. The reaction was cooled down and the precipitated solids were collected and dried to afford the diol (4c) (3.8g, yield 65%, purity 97%) as a white solid. MS (ESI) m/z 169.2 [M+H]+., 127956-11-0
The synthetic route of 127956-11-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Wang, Xueyuan; Bai, Enhe; Zhou, Hui; Sha, Sijia; Miao, Hang; Qin, Yanru; Liu, Zhaogang; Wang, Jia; Zhang, Haoyang; Lei, Meng; Liu, Jia; Hai, Ou; Zhu, Yongqiang; Bioorganic and Medicinal Chemistry; vol. 27; 3; (2019); p. 533 – 544;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics