With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.127956-11-0,Methyl 4-oxotetrahydro-2H-pyran-3-carboxylate,as a common compound, the synthetic route is as follows.
To a suspension ofguanidine hydrochloride (906 mg, 9.48 mmol) in ethanol (30 mL) was added sodium ethoxide (4.03 mL, 9.48 mmol) and the resulting mixture was stirred at room temperature for 10 mm before addition of methyl 4-oxotetrahydro-2H-pyran-3- carboxylate (1 .00 g, 6.32 mmol) in ethanol (35 mL). The reaction mixture was heatedat 80 00 overnight then concentrated to dryness, the residue was diluted with water and the pH was adjusted to 4 with HCI (iN, aq.). The resulting mixture was stirred at room temperature for 2 hours. The precipitated solids were isolated by filtration, washed with water and dried in vacuo to give the titled compound as a light yellow solid (860 mg, 81%).1H NMR (400 MHz, DMSO-d6) 6 ppm 2.36 (t, J = 5.56 Hz, 2 H),3.77 (t, J = 5.56 Hz, 2 H), 4.24 (s, 2 H), 6.34 (s, 2 H), 10.78 (s, 1 H)., 127956-11-0
As the paragraph descriping shows that 127956-11-0 is playing an increasingly important role.
Reference£º
Patent; JANSSEN SCIENCES IRELAND UC; JONCKERS, Tim, Hugo, Maria; RABOISSON, Pierre, Jean-Marie, Bernard; GUILLEMONT, Jerome, Emile, Georges; MC GOWAN, David, Craig; EMBRECHTS, Werner, Constant, Johan; COOYMANS, Ludwig, Paul; CALMUS, Laurent; (18 pag.)WO2018/2319; (2018); A1;,
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