With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2081-44-9,Tetrahydro-2H-pyran-4-ol,as a common compound, the synthetic route is as follows.
General procedure: In the following Reaction Scheme A-2 Butyl 4-hydroxypiperidine-1-carboxylate (1 eq.) Or tetrahydro-2H-p yr-4-ol (1 eq.),Methanesulfonyl chloride (MsCl, 1 eq.),Triethylamine (Et3N, 1 eq.) And 4-dimethylaminopyridine (DMAP, 0.4 eq.) Were dissolved in dichloromethane at 0 C and stirred at room temperature for 12 hours.Water was added to the reaction solution at 0 C and extracted three times with dichloromethane.The combined organic solvent layers were dried with magnesium sulfate and concentrated.This was purified by column chromatography to obtain a compound substituted with methanesulfonate.Subsequently, 4-iodo-1H-pyrazole (1 eq.) Was dissolved in DMF, cooled to 0 C, 60% sodium hydride (NaH, 1.2 eq.) Was added to the solution and the mixture was stirred at room temperature for 1 hour.The previously obtained compound (1.1 eq) was added to the reaction solution, and the mixture was heated and stirred at 100 C.Water was added to the reaction solution at 0 C, extracted three times with ethyl acetate, and the combined organic solvent layer was dried over magnesium sulfate.The obtained organic solvent layer was concentrated and purified by column chromatography to obtain an intermediate.
2081-44-9, The synthetic route of 2081-44-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Institute for Basic Science; KAIST; Hong Seung-u; Ma Sin-mi; Hong Sun-seon; Jeong Hoe-yun; (71 pag.)KR2019/23557; (2019); A;,
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