1172623-99-2, tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-hydroxytetrahydro-2H-pyran-3-yl)carbamate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Ruthenium chloride (45 mg) was added to a solution oftert-butyl[(2R,3S)-5-hydroxy-2-(2,5-difluorophenyl)tetrahydro-2H-pyran-3-yl]carbamate (15.0 g; Formula IX;Example 10) and acetic acid (15.0 mL) in acetonitrile (45.0 mL) and water (7.5 mL) at0C. Sodium bromate (4.0 g) was added slowly to the reaction mixture at 0C to 5C overS hours, and then the mixture was stirred for 16 hours at -5C to 5C. After completion ofthe reaction, IPA (15 mL) was added over 25 minutes at 0C to 5C, and then the mixture was stirred for 15 minutes. Water (180 mL) was slowly added to the reaction mixture, and then the mixture was stirred for 5 hours at 0C to 5C. The reaction mixture was filtered, and then dried under reduced pressure at 45C to 50C to obtain the title compound.Yield: 80%, 1172623-99-2
The synthetic route of 1172623-99-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SUN PHARMACEUTICAL INDUSTRIES LIMITED; PANDYA, Bhargav; THAKUR, Mandeep; SURADKAR, Swapnil; ANGADI, Surender; (42 pag.)WO2017/81590; (2017); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics