With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2081-44-9,Tetrahydro-2H-pyran-4-ol,as a common compound, the synthetic route is as follows.
2081-44-9, To a solution of tetrahydropyran-4-ol (1.0 g, 9.8 mmol) in DCM (5 mL) was added Et3N (triethylamine; 2.73 mL, 20 mmol). To the mixture was added a solution of methanesulfonyl chloride (0.91 mL, 12 mmol) in DCM (dichloromethane; 5 mL) at 0 C. The mixture was stirred at 0 C for 1 hour. Upon completion, the reaction mixture was treated with water (5 mL), and extracted with DCM (10 mL x 3). The organic layers were combined, washed with brine (10 mL x 3), dried over Na2S04, filtered and concentrated under reduced pressure to afford tetrahydropyran-4-yl methanesulfonate (1.3 g, crude) as a white solid, which was used directly in the next step.
2081-44-9 Tetrahydro-2H-pyran-4-ol 74956, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; SYROS PHARMACEUTICALS, INC.; ZHANG, Yi; AUSTGEN, Kathryn; CHUAQUI, Claudio Edmundo; MALOJCIC, Goran; SINKO, William; CIBLAT, Stephane; JAMES, Clint; GUAN, Huiping Amy; SAVOIE, Tracey Lodie; (179 pag.)WO2019/14513; (2019); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics