With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.85064-61-5,Tetrahydropyranyl-4-acetic acid,as a common compound, the synthetic route is as follows.
Example 1-29 l-(l-(4-Chloro-2-fluorobenzyl)-3-(trif uoromethyl)-4,5-dihydro-lH-pyrazolo[3,4- c]pyridin-6(7H)-yl)-2-(tetrahydro-2H-pyran-4-yl)ethanone To a solution of 2-(tetrahydro-2H-pyran-4-yl)acetic acid (52 mg, 0.36 mmol, 1.2 eq), 1- (4-chloro-2-fluorobenzyl)-3-(trifluoromethyl)-4,5,6,7-tetrahydro-lH-pyrazolo[3,4- c]pyridine hydrochloride (Intermediate 2-1) (110 mg, 0.30 mmol, 1.0 eq) and HATU (171 mg, 0.45 mmol, 1.5 eq) in DMF (2 mL) was added N,N-diisopropylethylamine (77 mg, 0.60 mmol, 2.0 eq). The mixture was stirred at room temperature for 16 h and diluted with water (100 mL). The mixture was extracted with EtOAc (100 mLX 3). The combined organic layers were dried over anhydrous sodium sulfate and concentrated. The residue was purified by prep-HPLC (TFA method) to afford l-(l-(4-chloro-2- fluorobenzyl)-3-(trifluoromethyl)-4,5-dihydro-lH-pyrazolo[3,4-c]pyridin-6(7H)-yl)-2- (tetrahydro-2H-pyran-4-yl)ethanone as a yellow oil (131 mg, yield 95percent). 1H NMR (400 MHz, Methanol-d4) delta: 7.31-7.16 (m, 3H), 5.41-5.36 (m, 2H), 4.71-4.70 (m, 2H), 3.92- 3.87 (m, 2H), 3.82-3.75 (m, 2H), 3.45-3.35 (m, 2H), 2.76-2.63 (m, 2H), 2.45-2.34 (m, 2H), 2.06-1.92 (m, 1H), 1.68-1.59 (m, 2H), 1.39-1.26 (m, 2H); LCMS (ESI) m/z 459.9 [M+H]+, 85064-61-5
As the paragraph descriping shows that 85064-61-5 is playing an increasingly important role.
Reference£º
Patent; BIOGEN MA INC.; KUMARAVEL, Gnanasambandam; PENG, Hairuo; XIN, Zhili; WO2015/188051; (2015); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics