873397-34-3,873397-34-3, Tetrahydro-2H-pyran-3-carboxylic acid is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Synthesis of tetrahydro-2H-pyran-3-carboxylic acid:DCC (7.85 g, 38.1 mmol) was added to tetrahydro-2H-pyran-3-carboxylic acid (4.5 g, 34.6 mmol) in THF (100 mL) at 0 ¡ãC. The reaction mixture was stirred at room temperature for 1 h and cooled down to 0 ¡ãC. N-Hydroxysuccinimide (4.78 g, 41.5 mmol) was added and stirring was continued overnight at room temperature. The reaction mixture was filtered, the solvent was evaporated, and the residue was purified by column chromatography (silica gel, EtOAc/Hept, 1 :1-1 :0) to prepare 2,5-dioxopyrrolidin-l-yl tetrahydro-2H-pyran-3-carboxylate (6.5 g, 83percent yield). 1H NMR (300 MHz, CDCI3/TMS): delta 4.14-4.06 (m, 1H), 3.88-3.79 (m, 1H), 3.71-3.64 (m, 1H), 3.54-3.44 (m, 1H), 2.99-2.89 (m, 1H), 2.81 (s, 4H), 22.2-2.14 (m, 1H), 1.95-1.84 (m, 1H), 1.78-1.64 (m, 3H).
The synthetic route of 873397-34-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ENVIVO PHARMACEUTICALS, INC.; RIPKA, Amy; SHAPIRO, Gideon; MCRINER, Andrew; WO2012/40230; (2012); A1;,
Tetrahydropyran – Wikipedia
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