With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1194-16-7,2,2-Dimethyltetrahydropyran-4-one,as a common compound, the synthetic route is as follows.
Cap- 188, step aTo a solution of 2,2-dimethyldihydro-2H-pyran-4(3H)-one (2 g, 15.60 mmol) in 50 niL of MeOH was slowly added sodium borohydride (0.649 g, 17.16 mmol). The resulting mixture was stirred at room temperature for 3 hours. To the mixture was then added 1 N HCl aqueous solution until it crosses into acidic pH range and then extracted with EtOAc (3X). The combined organic layers were dried withMgS04 and concentrated to afford Cap-188, step a (1.9 g) as clear oil. The product was used in the next step without purification. XH NMR (400 MHz, CDCI3) delta ppm 3.91 – 4.02 (1 H, m), 3.79 – 3.86 (1 H, m), 3.63 (1 H, td, J=12.05, 2.51 Hz), 1.82 – 1.93 (2 H, m), 1.40 – 1.53 (1 H, m), 1.29 – 1.38 (1 H, m), 1.27 (3 H, s), 1.20 (3 H, s), 1194-16-7
The synthetic route of 1194-16-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; BELEMA, Makonen; SRINIVASU, Pothukanuri; BENDER, John A.; LOPEZ, Omar D.; CHEN, Qi; RAMPULLA, Richard A.; GUPTA, Samayamunthula Venkata Satya Arun Kumar; MEANWELL, Nicholas A.; WO2012/21591; (2012); A1;,
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