2081-44-9, Tetrahydro-2H-pyran-4-ol is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a mixture of NaH (1.8 g, 40 mmol) in anhydrous THF (10 mL) was added reagent 1 (2.0 g, 20 mmol). The mixture was stirred at room temperature for 1 h before addition of a solution of 4-methylbenzene-1 -sulfonyl chloride (4.6 g, 24 mmol) in THF (10 mL). The resulting mixture was stirred at room temperature for 15 h. The solution was quenched with saturated, aqueous NH4CI solution (30 mL). The mixture was extracted with EtOAc (100 mL x 3). The combined organic layers were dried over Na2S04 and evaporated to dryness. Flash chromatography (silica, petroleum ether : EtOAc 100:1 to 1 :1 ) gave reagent 2 (4.7 g, 92%). 1H NMR (CDCIs) delta 7.79 (d, J = 8.4 Hz, 2 H), 7.33 (d, J = 4.0 Hz, 2 H), 4.64-4.70 (m, 1 H), 3.82-3.87 (m, 2 H), 3.42-3.48 (m, 2 H), 2.43 (s, 3 H) , 1 .75-1.87 (m, 2 H), 1 .68-1.74 (m, 2 H)., 2081-44-9
2081-44-9 Tetrahydro-2H-pyran-4-ol 74956, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; H. LUNDBECK A/S; ESKILDSEN, J¡ãrgen; WO2014/49133; (2014); A1;,
Tetrahydropyran – Wikipedia
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