With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.220641-87-2,N-Methyltetrahydro-2H-pyran-4-amine,as a common compound, the synthetic route is as follows.
A solution of N-methyl-(tetrahydro-pyran-4-yl)-amine (0.25 g, 2.17 mmol), Cs2CO3 (1.41 g, 4.34 mmol) and compound 4 (0.85 g, 2.17 mmol) in THF (20 mL) is stirred at room temperature for 72 h. The reaction mixture is filtered through Celite , the solids are washed with ethyl acetate and DCM and the filtrate is concentrated under reduced pressure. The residue is purified by column chromatography (silica, eluent: heptanes, 50-100% ethyl acetate) to yield 374 mg of compound 5. Yield 41%;. LC-MS (LC Method b): retention time: 1.51 min, m/z 424 [M+H], 220641-87-2
As the paragraph descriping shows that 220641-87-2 is playing an increasingly important role.
Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BARTOLOZZI, Alessandra; HICKEY, Eugene, Richard; RIETHER, Doris; WU, Lifen; ZINDELL, Renee; BLUMIRE, Nigel; ERMANN, Monika; GLENN, Edward, Thomas; KHOR, Someina; ZAWADZKI, Przemyslaw; WO2010/147792; (2010); A2;,
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