With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4677-18-3,2-(Tetrahydro-2H-pyran-4-yl)ethanol,as a common compound, the synthetic route is as follows.
d) To a solution of 300 mg (2.2 mmol) of 2-(tetrahydro-2H-pyran-4-yl)ethanol in 10 mL of DCM at 05C TEA (0.38 mL, 2.7 mmol) and methanesulfonyl chloride (0.19 mL, 2.5 mmol) were added. The mixture was allowed to warm to room temperature and stirred at this temperature overnight. The reaction was stirred with saturated NaHC03 for 15 min and the aqueous phase was extracted with DCM (x3). The combined organic layers were dried over MgS04, filtered and concentrated to quantitatively yield 2-(tetrahydro-2H-pyran-4-yl)ethyl methanesulfonate as a colorless oil.
4677-18-3, 4677-18-3 2-(Tetrahydro-2H-pyran-4-yl)ethanol 17750944, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; LABORATORIOS DEL DR. ESTEVE, S.A.; DRACONIS PHARMA, S.L.; ALMIRALL, S.A.; TORRENS JOVER, Andoni; MERCE VIDAL, Ramon; CALDENTEY FRONTERA, Francesc Xavier; RODRIGUEZ GARRIDO, Antonio, David; CARCELLER GONZALEZ, Elena; SALAS SOLANA, Jordi; WO2013/37960; (2013); A1;,
Tetrahydropyran – Wikipedia
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