With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.137052-08-5,1-(Tetrahydro-2H-pyran-4-yl)ethanone,as a common compound, the synthetic route is as follows.
General procedure: Mn(CO)5Br (16.2 mg; 6 mol%) and ligand L4a (6.6 mg; 2 mol%) were added under a flow of argon to a flame dried 25 mL Schlenk flask containing a PTFE coated stirring bar. After three vacuum/argon cycles 2 mL of isopropyl alcohol were added to the Schlenk flask. The yellowish suspension was stirred for 10 min at room temperature and another 2 mL of isopropyl alcohol, containing potassium tert-butoxide (22.4 mg; 20 mol%), were added via syringe to the continuously stirred solution. After 10 min the Substrate (1 mmol) was added to clear yellow reaction solution and the glas wall of the Schlenk flask was rinsed with 2 mL of isopropyl alcohol. The Schlenk flask was placed in a heating block, heated to 80 C and kept at this temperature for 20 hours. After this time the Schlenk flask was removed from heating block and was allowed to cool to room temperature. The reaction solution was filtered through a small pipette plug of silica and the silica was washed with additional isopropyl alcohol. The conversion and yield of the reaction were determined by GC using hexadecane as internal standard. The ee value of the reaction was measured either by GC or HPLC.
137052-08-5, As the paragraph descriping shows that 137052-08-5 is playing an increasingly important role.
Reference£º
Article; Schneekoenig, Jacob; Junge, Kathrin; Beller, Matthias; Synlett; vol. 30; 4; (2019); p. 503 – 507;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics