With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1194-16-7,2,2-Dimethyltetrahydropyran-4-one,as a common compound, the synthetic route is as follows.
General procedure: A solution of trimethyl phosphonoacetate (9.36 mmol) in THF (7 mL, 1.34 M) was added dropwise to sodium hydride (60% in mineral oil, 9.75 mmol) suspended in THF (35 mL) at 0 C. After 40 min, the pyranone (7.80 mmol), in THF (7 mL, 1.11 M), was added dropwise and the flask was heated to 25 C. After 19 h, the mixture was cooled to room temperature and quenched with saturated aqueous NH4Cl (10 mL). The precipitate was removed by filtration and the layers were separated. The aqueous layer was extracted with ether (2*20mL) and the organic fractions were combined, dried (MgSO4), filtered, and concentrated under vacuum. The crude material was purified as indicated., 1194-16-7
As the paragraph descriping shows that 1194-16-7 is playing an increasingly important role.
Reference£º
Article; Shouksmith, Andrew E.; Evans, Laura E.; Tweddle, Deborah A.; Miller, Duncan C.; Willmore, Elaine; Newell, David R.; Golding, Bernard T.; Griffin, Roger J.; Australian Journal of Chemistry; vol. 68; 4; (2015); p. 660 – 679;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics