185815-59-2, 4-Isobutyldihydro-2H-pyran-2,6(3H)-dione is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A solution of (+/-)-1-(1-napthyl)ethanol XIII (20.2 g, 117.29 mmole) in tert- butyl methyl ether (50 ml) was added to a solution of the anhydride VIII (20 g, 117.50 mmole) in terf-butyl methyl ether (50 ml) at – 78 C under an atmosphere of nitrogen. DABCO (3.2 g, 28.53 mmole) was added to it and the reaction mixture was maintained at this temperature for 2 h when the reaction was complete as indicated from the TLC.An aqueous solution of citric acid was added to the reaction mixture and it was allowed to warm up to room temperature. The organic layer was washed with an aqueous solution of citric acid (3 chi 50 ml), water (3 * 50 ml) and brine (3 chi 50 ml), dried over sodium sulfate and concentrated to give the ester XII; yield 40 g, quantitative. The crude product was carried on to the following step without further purification.
185815-59-2, 185815-59-2 4-Isobutyldihydro-2H-pyran-2,6(3H)-dione 11480690, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; Dr. Braja Sundar Pradhan; WO2012/93411; (2012); A2;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics