With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.101691-94-5,4-(Iodomethyl)tetrahydro-2H-pyran,as a common compound, the synthetic route is as follows.
A mixture of intermediate XIX.1 (500 mg; 1.21 mmol) and 4-iodomethyl-tetrahydropyrane (1.07 g; 4.73 mmol) in ACN (5.0 ml) is heated to 120 C. (microwave heating; closed vessel) for 7 h. Additional 4-iodomethyl-tetrahydropyran (1.07 g; 4.73 mmol) is added and the mixture is again heated to 120 C. (microwave heating; closed vessel) over night. Volatiles are evaporated and the crude product is purified by RP-HPLC (modifier: TFA) to yield the title compound. [0212] C25H40ClN4O5¡ÁC2F3O2 ESI Mass spectrum: m/z=511 [M]+, 101691-94-5
The synthetic route of 101691-94-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Boehringer Ingelheim International GmbH; KLEY, Joerg; FRATTINI, Sara; HAMPRECHT, Dieter; US2015/18315; (2015); A1;,
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