Brief introduction of 4677-18-3

The synthetic route of 4677-18-3 has been constantly updated, and we look forward to future research findings.

4677-18-3,4677-18-3, 2-(Tetrahydro-2H-pyran-4-yl)ethanol is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: DIPEA (9.42mmol) was added to a solution of N-(tert-butoxycarbonyl)-1-methyl-d-tryptophan (3.14mmol), the appropriate alcohol or amine (3.14mmol) and HATU (3.14mmol) in acetonitrile (30mL) at 0C, and the solution was allowed to warm to rt. After stirring overnight (17h), the reaction was diluted with water (50mL) and the product was extracted with CH2Cl2 (3¡Á50mL). The combined organic extract was washed with water (25mL), brine (25mL) dried over Na2SO4 and concentrated under reduced pressure to afford the crude. Chromatographic purification afforded the desired product.

The synthetic route of 4677-18-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Adams, James; Brincks, Erik L.; Jaipuri, Firoz A.; Kumar, Sanjeev; Link, Charles; Marcinowicz, Agnieszka; Mautino, Mario R.; Potturi, Hima; Vahanian, Nicholas; Van Allen, Clarissa; Waldo, Jesse P.; Zhuang, Hong; European Journal of Medicinal Chemistry; vol. 198; (2020);,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics