With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.137052-08-5,1-(Tetrahydro-2H-pyran-4-yl)ethanone,as a common compound, the synthetic route is as follows.
137052-08-5, Under nitrogen protection,(R) -MeCBS (718.3 mL, 1 M solution in toluene) was added to a solution of borane dimethyl sulfide (718.3 mL, 7.183 mol) in tetrahydrofuran (4.6 L) at -10 to 0 C.Maintain low temperature conditions,Compound 15 (920 g, 7.183 mol) was added dropwise to the reaction system.After completion of the dropwise addition,The reaction system was stirred at 0 to 5 C for 10 minutes.(2N, 4L) was added slowly at -5 to 0 C to quench the reaction,After stirring for 6 hours, sodium chloride was added until saturation,Methyl tert-butyl ether (2 L) was added and stirred for 5 minutes,The filter cake was rinsed with methyl tert-butyl ether (2 L).The filtrate was allowed to stand,The aqueous phase was extracted with methyl tert-butyl ether until the desired product was not detected in the aqueous phase.The organic phases were combined,And washed with saturated brine (5 L)Dried over anhydrous sodium sulfate,Concentration by filtration afforded crude compound 16 (846 g) as a pale yellow oil,Without further purification,Can be directly used for the next reaction,e.e. value of the compound 16 of Example 10 derived by the reaction was carried out by.
As the paragraph descriping shows that 137052-08-5 is playing an increasingly important role.
Reference£º
Patent; Medchemexpress China Co., Ltd.; Wang, Guangyong; Li, Chaoping; Zhou, Zhiguo; Gao, Qiang; Zheng, Baofu; (12 pag.)CN105669647; (2016); A;,
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