With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.110238-91-0,Methyl tetrahydro-2H-pyran-4-carboxylate,as a common compound, the synthetic route is as follows.
Into a 100 mL round-bottom flask, were placed a solution of compound 19.1 (200 mg, 1.39 mmol, 1.00 equiv) in THF (50 mL) and LiA1H4 (63 mg, 1.66 mmol, 1.20 equiv). Reaction was stirred for 3 h at room temperature and then quenched using NaSO4.10H20. The solids were filtered out. Resulting solution was concentrated under vacuum furnish 150 mg (crude) of oxan-4-ylmethanol as a yellow solid.
110238-91-0, 110238-91-0 Methyl tetrahydro-2H-pyran-4-carboxylate 2773520, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; NIMBUS IRIS, INC.; ROMERO, Donna L.; MASSE, Craig E.; ROBINSON, Shaughnessy; GREENWOOD, Jeremy Robert; HARRIMAN, Geraldine; WO2015/48281; (2015); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics