With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.25637-16-5,4-Bromotetrahydropyran,as a common compound, the synthetic route is as follows.
Compound 10-rac (100 mg, 0.28 mmol) and 37 4-bromotetrahydropyran (94 mg, 0.56 mmol) were dissolved in 5mL 31 DMF, and then the solution was added with 25 K2CO3 (78 mg, 0.56 mmol) and reacted at 90C for 40 h. After the reaction finished, the mixture was poured into water and extracted with EtOAc (40 mL¡Á3). The ethyl acetate layers were combined and washed with water and saturated salt solution, then dried over anhydrous sodium sulfate and filtered, and the filtrate was vacuum concentrated to give a crude product, which was purified by a preparation plate to give Compound 3a-rac (65 mg, 56.1% yield)., 25637-16-5
25637-16-5 4-Bromotetrahydropyran 13349654, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; Ginkgo Pharma Co., Ltd.; CHEN, Li; ZHAI, Peibin; SHAO, Qing; WU, Jin; LI, Xiaowen; (46 pag.)EP3492467; (2019); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics