With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.61363-56-2,2H-Pyran-3,5(4H,6H)-dione,as a common compound, the synthetic route is as follows.
61363-56-2, Under a nitrogen atmosphere,In a 5 mL reaction tube with a Teflon magnetic stir bar,Add 0.30 mmol of 2H-pyran-3,5(4H,6H)-dione,1.0 mL 1,2-dichloroethane,0.060 mmol of 2-dimethylaminopyridine,0.45 mmol of ethyl trifluoroacetate,The reaction was stirred in an oil bath at 120 C for 16 h in a closed system and then cooled to room temperature.Combine the organic phase,Extracted with saturated ammonium chloride solution and ethyl acetate.The organic solvent is removed by rotary evaporation to obtain a crude product.The crude product was subjected to silica gel column chromatography.Elected with n-pentane and dichloromethane,get4-(trifluoromethyl)pyrano[3,4-b]pyran-2,5(6H,8H)-Diketone(Isolation yield 43%).
As the paragraph descriping shows that 61363-56-2 is playing an increasingly important role.
Reference£º
Patent; Fuzhou University; Weng Zhiqiang; Yan Weitao; Wu Wei; (12 pag.)CN109232416; (2019); A;,
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