951127-25-6, tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,951127-25-6
12b (0.28 g, 1.2 mmol) was dissolved in dimethylacetamide (4 mL) at room temperature,Intermediate 1 (0.39 g, 1.2 mmol) and benzenesulfonic acid (0.22 g, 1.2 mmol) were added and stirred at room temperature for 1 hour.Sodium tris (acetoxy) borohydride (0.33 g, 1.4 mmol) was added to the reaction solution, and the reaction was continued at room temperature for 16 hours.After cooling to 0 C, water (30 mL) and ammonia (1 mL) were added successively to precipitate a white solid which was filtered and washed with water (10 mL x 2) and dried.The filter cake was dissolved in dichloromethane (150 mL), dried over anhydrous magnesium sulfate, filtered and the filtrate was concentrated under reduced pressure to give soil yellow solid 12c (0.30 g, yield 46.0%).
951127-25-6 tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate 44193925, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; Sichuan Haisco Pharmaceutical Co.,Ltd; FAN, JIANG; CHEN, QINGPING; JIANG, WEI; ZHENG, SUXIN; YE, FEI; (128 pag.)TW2017/8221; (2017); A;,
Tetrahydropyran – Wikipedia
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