125552-89-8, 4-(Bromomethyl)tetrahydropyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Into a round bottomed flask equipped with a nitrogen inlet and a magnetic stir bar, (4- (lH-benzo[d]imidazol-2-yl)piperidin-l-yl)(3-fluoro-4-methoxyphenyl)methanone (250 mg, 0.71 mmol), NaH (60 % in oil, 62 mg, 1.55 mmol) and 2 mL DMF were added and stirred at room temperature for 2 hours. Solution of 4-(bromomethyl)tetrahydro-2H-pyran (190 mg, 1.06 mmol) in 0.2 mL of DMF was then slowly added to the above solution. The reaction mixture was then allowed to reflux for 4 hours. Water was then added to the reaction mixture and stirred for 15 minutes. The sticky solid formed was filtered and washed with water. The solid was purified using the combifiash purification system with 2-5 % MeOH in CH2Cl2 to give 100 mg (31 %) of white solid as the pure and desired compound. (0604) lH NMR (400 MHz, Chloroform-c/) delta 7.78 (d, J = 6.5 Hz, 1H), 7.42 – 7.33 (m, 1H), 7.33 – 7.21 (m, 4H), 7.00 (t, J = 8.4 Hz, 1H), 5.32 (s, 2H), 4.08 (d, J= 7.3 Hz, 2H), 4.01 (dd, J = (0605) 12.3, 3.6 Hz, 2H), 3.94 (s, 3H), 3.34 (td, J= 11.5, 2.9 Hz, 2H), 3.19 – 2.96 (m, 3H), 2.34 – 2.11 (m, 3H), 1.99 (d, J = 13.6 Hz, 2H), 1.65 – 1.38 (m, 4H). 1 C NMR (101 MHz, Chloroform-c ) delta 169.12, 156.58, 149.06, 128.38, 123.80, 119.44, 115.56 (d, J = 19.9 Hz), 112.99, 109.78, 67.34, 56.30, 53.45, 49.32, 36.04, 34.54, 31.29, 30.81. LCMS: Expected: 452 (M+H)+; Found: 452. (0606) HRMS:- Found: 452.23518 (M+H)+; Theoretically = 452.23440.
125552-89-8, The synthetic route of 125552-89-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA; KHANNA, May; KHANNA, Rajesh; GOKHALE, Vijay; CHAWLA, Reena; (186 pag.)WO2018/144900; (2018); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics